Your Impact

For millions of people across the globe, medications mean the difference between life and death. For others, they also mean the difference between comfort and pain, and living a normal life versus being limited in daily activities. While new medications have the power to both save lives and improve quality of life for patients with chronic health conditions, the process of bringing a new medication to market for patients in need can take more than a decade and can cost billions of dollars.

Bhanushee Sharma, who recently completed her Ph.D. in chemical engineering at Rensselaer Polytechnic Institute, was determined to solve this problem. As part of the Artificial Intelligence Research Collaboration (AIRC), a joint effort between Rensselaer and IBM to advance AI research, she worked on a project aimed at improving the drug discovery process through artificial intelligence (AI) and machine learning techniques.

The current drug discovery process involves both preclinical research, which tests drugs in cells or animals, and clinical research, which tests drugs in people. Sharma, who was advised by Professor Jonathan Dordick and Professor James Hendler at Rensselaer and mentored by Payel Das, research staff member at IBM and manager of AI science at the Thomas J. Watson Research Center, looked at data collected in both preclinical and clinical trials to develop machine learning models that predict the toxicity of drugs before they enter testing in humans.

“Even though a large number of drugs are discovered, very few are actually approved because they end up being toxic in humans or not effective in humans,” Sharma said. “If we have a better idea of the toxicity of these drugs, then we can design drugs that are more likely to receive approval.”

While machine learning models have been developed to predict drug toxicities, many of them have been developed in a way that humans cannot understand. Therefore, one of Sharma’s goals was to develop a model that explains predictions so that scientists can better understand why a prediction has been made. Her explainable AI-based model paves the way for models that scientists can interact with more directly.

“We have many different diseases that we are still trying to find drugs for,” she said. “If we have a quicker and less costly drug discovery process, then we can combat more diseases more quickly.”

Sharma, who graduated in August, plans to enter the biotechnology or pharmaceutical sectors where she hopes to continue to apply machine learning and AI techniques to improve human health.

I am pursuing a dual major in biology and philosophy. I originally planned to study biology since I have always enjoyed the topic and the research. However, I fell in love with the philosophy department – they offer a variety of classes that allow a break from the structured science classes we all have to take. These classes are more discussion-based, and the professors allow for our thoughts and ideas to be considered as actual solutions.

RPI cares a lot about the success of its students. We have opportunities for hands-on research, as well as classes that are specific to the variety of interests of students like me. In fact, if there is an area that isn’t listed, they can help you set up an independent study for it! RPI also offers internships in the field you are studying to gain experience and to secure a job after graduation.

I am also so grateful for my Air Force ROTC opportunity. My dream has always been to serve in the military. Through ROTC, I can succeed in my future goals while also obtaining a degree. After graduation, I plan to commission into the United States Air Force as a biomedical laboratory technician or an RPA pilot.

Without the help of alumni, parents, families, and friends, I don’t think I could have attended RPI. I was able to go to my dream school, thanks to the scholarships I received. My time here at Rensselaer has been truly memorable, and I can’t wait to see what else is to come.